Changes in an office practice of menopause in the last 25 years.

375 Increased cardiac and stroke death risk in the first year after discontinuation of postmenopausal hormone therapy Minttu Venetkoski, MD, Hanna Savolainen-Peltonen, MD, PhD, Päivi Rahkola-Soisalo, MD, PhD, Fabian Hoti, MSc, Pia Vattulainen, MSc, Mika Gissler, PhD, Olavi Ylikorkala, MD, PhD, and Tomi S. Mikkola, MD, PhD Discontinuation of postmenopausal hormone therapy is associated with increased risk of cardiac and stroke death during the first year after treatment, particularly in women younger than 60 years of age. Menopause